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Coronavirus: Is there any Promising Drug to Cure Covid 19?


Coronavirus: Is there any Promising Drug to Cure Covid 19?

World is battling with Covid 19 and are in urge for making the most efficient and effective treatment for this pandemic. 

Clinical trials are progressing each countries to find a compatible treatment. UK is running the world’s largest clinical trials , called Recovery in Oxford University with more than 12,000 patients. A third phase of trial is now enough for giving a promising vaccine.


WHO is running the solidarity trial to access promising treatments all around the world.

India is also in the progressive process of treatment trials.

Last day USA president Trump gave a promising updates to their clinical trials and they ensured the fastest processing of the treatment.

Multiple pharmaceutical companies are running trials of their own.

The world are in hope for the beneficial treatment’s arrival.

Now what about the drugs,

Is there any Promising drug for Covid 19?

 Yes, of all the drugs being trialed, only one has been been proven to save lives - Dexamethasone

Dexamethasone is a corticosteroid used in a wide range of conditions for its anti-inflammatory and immunosuppressant effects.

It was tested in hospitalized patients with COVID-19 in the United Kingdom’s national clinical trial RECOVERY and was found to have benefits for critically ill patients.

According to preliminary findings shared with WHO (and now available as a preprint), for patients on ventilators, the treatment was shown to reduce mortality by about one third, and for patients requiring only oxygen, mortality was cut by about one fifth.

Crucially it is also cheap which means it could be used all around the world.

However, the drug does not work on people with milder symptoms.

What about other Drugs ?

Several types of drugs are being studied to treat COVID-19. Most of the drugs are antiviral drugs that have previously been used for other conditions. 

On March 28, 2020, the U.S. Food and Drug Administration (FDA) issued an EUA to allow hydroxychloroquine sulfate and chloroquine phosphate donated to the Strategic National Stockpile (SNS) to be distributed and used for hospitalized COVID-19 patients. In fact, these two drugs have been used for decades for the therapy and control of malaria and autoimmune diseases.

Among the antiviral medications are favipiravir, or Avigan, which was used to treat influenza in Japan; remdesivir, which was tested on Ebola; ritonavir-lopinavir, an antiviral drug given to HIV patients; and ribavirin which is used for hepatitis C and other viral hemorrhagic fevers. 

Malaria drugs,Chloroquine

Many people claiming there is recoveries with the malaria drug.
 
Chloroquine and the related drug, hydroxychloroquine, may have antiviral and immune-calming properties.

President Trump has used it as a preventative measure, and President Bolsonaro of Brazil has also taken it.

But despite some early studies raising hopes, one subsequent larger scale trial has shown it's not effective as a treatment.

However, the UK's Recovery trial found that hydroxychloroquine does not work as a treatment for Covid-19 and the WHO has stopped trialling the drug.

The World Health Organization (WHO) has halted its trials, saying that the drug doesn't reduce death rates in patients with coronavirus.
 
People with chronic diseases cannot treat with this drug, may cause other health issues.

Remdesivir

Remdisivir  is an antiviral drug that was originally developed to treat Ebola.

The broad-spectrum antiviral agent remdesivir (GS-5734; Gilead Sciences, Inc) is a nucleotide analog prodrug. On May 1, 2020, The US FDA issued EUA of remdesivir to allow emergency use of the agent for severe COVID-19 (confirmed or suspected) in hospitalized adults and children. [24, 25] A phase 1b trial of an inhaled nebulized version was initiated in late June 2020 to determine if remdesivir can be used on an outpatient basis and at earlier stages of disease. [161]

Remdesivir was studied in clinical trials for Ebola virus infections but showed limited benefit. [162] Remdesivir has been shown to inhibit replication of other human coronaviruses associated with high morbidity in tissue cultures, including severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012

Clinical trials of more than 1,000 people found it cut the duration of symptoms from 15 days to 11. It has not been shown to save lives, although studies are still continuing.

Initial findings suggest the treatment cut the odds of a patient in hospital developing severe disease, but larger clinical trials are now needed.
 
Lopinavir and Ritonavir

A pair of drugs called lopinavir and ritonavir are antiviral drugs that stop HIV from replicating.

There has been much talk and even early laboratory studies hinting they could be effective against coronavirus too.

However, the UK's Recovery trial showed they were ineffective and the WHO has also pulled the drugs from their Solidarity trial.

However, This decision applies only to the conduct of the Solidarity trial in hospitalized patients and does not affect the possible evaluation in other studies of hydroxychloroquine or lopinavir/ritonavir in non-hospitalized patients or as pre- or post-exposure prophylaxis for COVID-19. 

Favipiravir, Ribavirin 

Favipiravir, ribavirin have demonstrated effectiveness against SARS-CoV-2 in vitro – meaning in laboratory tests using cell cultures. 

Pharmaceutical giant Glenmark on Wednesday said its Phase-3 clinical trials of antiviral drug Favipiravir showed improvement in mild and moderate novel coronavirus patients.

In a statement on Wednesday, Glemnmark said Covid-19 patients administered with Favipiravir reported faster clinical cure and viral clearance as compared to those with routine care.

To date, there is no strong evidence of any drugs being effective against the virus in humans, regardless of the few case studies claiming treatments were effective on patients.   

Several ongoing clinical trials of the antiviral medications are expected to conclude at the end of the year. Only then can we obtain more evidence about which drugs, if any, effectively treat COVID-19. 

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